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Oral clindamycin disposition after single and multiple doses in normal cats
Author(s) -
BROWN S. ANTHONY,
DIERINGER T. M.,
HUNTER R. P.,
ZAYA M.J.
Publication year - 1989
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1989.tb00662.x
Subject(s) - cats , disposition , clindamycin , pharmacology , medicine , biology , psychology , antibiotics , microbiology and biotechnology , social psychology
Eighteen normal cats were randomly allocated into three treatment groups and dosed with clindamycin aqueous solution for 10 days at a dosage rate of: (1) 5.5 mg/kg b.i.d.; (2) 11 mg/kg b.i.d.; or (3) 22 mg/kg once daily. Serum disposition of clindamycin was determined after the first and last dose of clindamycin was given, and was analyzed using model‐independent pharmacokinetics by both the trapezoidal rule method and the predictive equation method. Complete blood counts and clinical chemistries were determined before and after the study. The trapezoidal rule method produced similar mean results with much less variance than the predictive equation method. Mean residence time was longer ( P < 0.05) after the high dose (393 ± 77 min) than after either the low or medium doses (276 ±51 and 274 ± 45 min, respectively). Oral volume of distribution ( V d(ss) / F ) after the high dose (3.06 ± 0.921/kg) was larger ( P < 0.05) than that after the low or medium doses (1.62 ± 0.30 and 1.76 ± 0.53 l/kg, respectively). Oral V d(ss) / F was significantly smaller ( P < 0.01) after the last dose than after the first dose when analyzed by treatment group. Significant ( P < 0.01) decreases in the leuko‐gram and erythrogram were observed, due to the large amount of blood collected for drug analysis. No clinical signs of drug intoxication were observed, and no drug‐related necropsy findings were found.