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Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus)
Author(s) -
GRONDEL J.L.,
NOUWS J. F. M.,
SCHUTTE A. R.,
DRIESSENS F.
Publication year - 1989
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1989.tb00657.x
Subject(s) - catfish , clarias gariepinus , rainbow trout , salmo , trout , oxytetracycline , zoology , pharmacokinetics , chemistry , fishery , biology , fish <actinopterygii> , pharmacology , antibiotics , biochemistry
Grondel, J.L., Nouws, J.F.M., Schutte, A.R. & Driessens, F. Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus). J. vet. Pharmacol. Therap. 12 , 157–162. A comparative pharmacokinetic study was conducted in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus) following intravenous (i.v.) and intramuscular (i.m.) administration of oxytetracycline (OTC) at a dose rate of 60 mg/kg body weight. Trout and catfish were kept in aerated tap water in tanks at constant temperatures of 12°C and 25°C, respectively. The two‐ and three‐compartment open models adequately described plasma drug disposition in African catfish and rainbow trout respectively, following i.v. OTC administration. Compared to catfish ( C o p = 86 ± 10 μg/ml) an eightfold higher extrapolated zero time concentration was obtained in trout ( C o p = 753 ± 290 μg/ ml). A significant difference was observed with respect to the relatively large apparent distribution volumes (Vd(area)) after i.v. OTC administration (trout, mean value: 2.1 l/kg; catfish, mean value: 1.3 l/kg). The mean final elimination half‐lives of both fish species were greater than previously reported in mammals (trout, 89.5 h; catfish, 80.3 h). A mean maximum plasma concentration (Cmax = 56.9 μg/ml) was obtained in trout at 4 h after i.m. administration of OTC. In catfish a lower C max of 43.4 (μg/ml was determined at about 7 h. No significant difference was observed with respect to bioavailability following i.m. administration of OTC (trout, 85%; catfish, 86%).