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Pharmacokinetics of single doses of gentamicin given intravenously and intramuscularly to turkeys
Author(s) -
PEDERSOLI W. M.,
RAVIS W. R.,
ASKINS D. R.,
KRISTA L. M.,
SPANO J. S.,
WHITESIDES J. F.,
TOLBERT D. S.
Publication year - 1989
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1989.tb00653.x
Subject(s) - gentamicin , pharmacokinetics , pharmacology , medicine , anesthesia , antibiotics , biology , microbiology and biotechnology
The disposition and absorption kinetics of gentamicin were studied in healthy, mature male and female turkeys ( n = 10). Single doses of gentamicin (5 mg/kg) were injected either i.v. or i.m. with a 30‐day rest period between each treatment. Baseline and serial venous blood samples (n = 17) were collected from each turkey. Serum concentrations of gentamicin were determined in duplicate for 24 h after each treatment, using radio‐immunoassay. Using nonlinear least‐square regression methods, the combined data of the i.v. and i.m. treatments were best described by a two‐compartment open model. Kinetic analysis of the data after a single i.v. dose provided the following mean values: t l/2α = 0.170 ± 0.093 h, t l/2α = 2.57 ± 0.79 h, MRT = 3.62 ± 0.96 h, V c = 0.090 ± 0.017 l/kg, V d(ss) = 0.172 ± 0.024 l/kg, V d(area) = 0190 ± 0.030 l/kg. and Cl t = 49.8 ± 9.8 ml/h/kg. After a single i.m. dose, the following mean values were determined: MRT = 5.10 ± 1.73 h, t 1/2 abs = 0.74 ± 0.66 h, t tag = 0.07 ± 0.19 h, Cl ± /F = 50.7 ± 12.5 ml/h/kg, V d(area / F = 0.193 ± 0.044 l/kg, and F = 102 ± 21%. Kinetic calculations made with the single i.m. data predicted that an i.m. injection of gentamicin at the dosage rate of 3 mg/kg q. every 12 h would provide average steady state serum concentrations of 4.93 μg/ml.