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Disposition kinetics of 2‐pyridine aldoxime methochloride in Bubalus bubalis
Author(s) -
SRIVASTAVA A. K.,
MALIK J. K.
Publication year - 1989
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1989.tb00648.x
Subject(s) - acetylcholinesterase , regimen , kinetics , pharmacology , chemistry , disposition , aché , enzyme , biochemistry , medicine , psychology , social psychology , physics , quantum mechanics
2‐Pyridine aldoxime methochloride (2‐PAM), an acetylcholinesterase (AChE) reactivator, is widely used in the treatment of organophos‐phate intoxication in man and animals (Taylor, 1980; Hatch, 1982). Among other factors, the therapeutic efficacy of AChE reactivators is dependent on the use of a suitable dosage regimen, so that during the course of therapy the concentration of drug in blood and target organs should not fall below the minimum effective concentration. Disposition kinetics of 2‐PAM have been calculated in man and laboratory animals (Sidell & Groff, 1971; Swartz & Sidell, 1974; DasGupta et al. , 1979). In the present study we have investigated disposition kinetics and dosage regimen of 2‐PAM and its effects on various blood enzymes in male buffalo calves after a single intravenous administration.