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Inhibition of rumination in sheep by α‐adrenoreceptor antagonists
Author(s) -
NICHOLSON T.,
OSMAN T. E. A.,
BELKHIRI M.
Publication year - 1988
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1988.tb00153.x
Subject(s) - rumination , pharmacology , psychology , chemistry , biology , neuroscience , cognition
Nicholson, T., Osman, T.E.A. & Belkhiri, M. Inhibition of rumination in sheep by α‐adrenoreceptor antagonists.J, vet. Pharmacol. Therap. 11 , 276–282, 1988. Rumination activity was recorded in sheep during a period of 3 h. The amount of rumination occurring in 30 min following the intravenous injection of an α blocking drug (prazosin, 0.1 mg/kg) and an a 2 blocking drug (idazoxan, 0.1 mg/kg) was reduced compared with control days when saline was given. The observation that rumination can be stimulated by a rapid, intravenous dose of adrenalin was confirmed. The induction of rumination by adrenalin was prevented by these α ‐adrenoreceptor antagonists given singly or together at the dose rate mentioned. These findings are discussed in the light of knowledge that normal reticulo‐ruminal motility and food intake can be inhibited by stimulation of α ‐adrenoreceptors.