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The effect of various antibacterial preparations on the in vitro morphology and chemotactic response of equine neutrophils
Author(s) -
PYCOCK J. F.,
ALLEN W. E.,
PORTER D.J.,
BOYD E. H.
Publication year - 1988
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1988.tb00140.x
Subject(s) - chemotaxis , in vitro , microbiology and biotechnology , chemistry , antibacterial activity , morphology (biology) , biology , bacteria , biochemistry , zoology , receptor , genetics
Pycock, J.F., Allen, W.E., Porter, D.J., Boyd, E.H. The effect of various antibacterial preparations on the in vitro morphology and chemotactic response of equine neutrophils. J. vet. Pharmacol. Therap. 11 , 191–196. Two independent assay systems were used to study the effect of three antibacterial preparations on in vitro morphology and chemotaxis of equine neutrophils. Incubation of neutrophils with high (200 μg/ml) and medium (20 μg/ml) concentrations of neomycin impaired their response to standard chemoattractants. Trimethoprim/sulfadoxine (0.4/2.0 μg/ml–40/200 μg/ml) and benzylpenicillin (0.25‐25 μg/ml) had no effect. Neutrophils collected from geldings 2 and 24 h after neomycin (5 mg/kg) administration had impaired responses to standard chemoattractants. Benzylpenicillin (13.2 mg/kg) had no effect.