Premium
Concentrations of immunoreactive leukotriene B 4 in uterine lavage fluid from mares with experimentally induced and naturally occurring endometritis
Author(s) -
WATSON E. D.,
STOKES C. R.,
BOURNE F.J.
Publication year - 1988
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1988.tb00133.x
Subject(s) - endometritis , endocrinology , medicine , uterus , ovariectomized rat , leukotriene , leukotriene b4 , estrous cycle , horse , andrology , chemistry , estrogen , biology , inflammation , pregnancy , paleontology , genetics , asthma
Watson, E.D., Stokes, C.R. & Bourne, F.J. Concentrations of immunoreactive leukotriene B 4 in uterine lavage fluid from mares with experimentally induced and naturally occurring endometritis. J. vet. Pharmacol. Therap. 11 , 130–134. Acute endometritis was induced in ovariectomized pony mares by infusion of a 1% solution of oyster glycogen. Maximum concentrations of immunoreactive leukotriene B 4 in uterine washings coincided with the greatest rate of infiltration of neutrophils into the uterine lumen. Concentrations of immunoreactive leukotriene B 4 decreased to basal levels 6 h after infusion and were unaffected by administration of ovarian steroids to ovariectomized mares. Uterine washings from mares with persistent endometritis did not contain significantly different concentrations of leukotriene B 4 from genitally normal mares.