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Hypnoanalgesia with R 8110/fentanyl in the dog: pharmacodynamic and pharmacokinetic interactions
Author(s) -
MONBALIU J.,
DEGRYSE A.D.,
OOMS L. A. A.,
DIJK. P. VAN,
LAGERWEIJ. E.,
MICHIELS M.,
WOESTENBORGHS R.,
HEYKANTS J.
Publication year - 1988
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1988.tb00122.x
Subject(s) - fentanyl , pharmacokinetics , chemistry , pharmacodynamics , anesthesia , narcotic , pharmacology , medicine
Monbaliu, J., Degryse, A.‐D., Ooms, L.A.A., Van Dijk, P., Lagerweij, E., Michiels, M., Woestenborghs, R. & Heykants, J. Hypnoanalgesia with R 8110/ fentanyl in the dog: pharmacodynamic and pharmacokinetic interactions. J. vet. Pharmacol. Therap. 11 , 63–70. The pharmacokinetics and clinical effects of the short‐acting hypnotic R 8110 and of the narcotic analgesic fentanyl were studied in the dog. The effects of separate intravenous (i.v.) injections of R 8110 (4 mg/kg) and fentanyl (0.015 mg/kg) and of concurrent i.v. injection of the two were studied. After administration of R 8110, induction of hypnosis occurred within 1 min, maximal depth of anaesthesia and satisfactory analgesia and muscle relaxation were obtained after 5 min. The effects had decreased within 15 min and full recovery occurred within 30 min. Fentanyl alone produced neither hypnosis nor muscle relaxation. When fentanyl and R 8110 were given simultaneously, the duration of hypnosis was doubled in comparison with R 8110 alone. Moreover, markedly improved and longer lasting analgesia and muscle relaxation were observed with the combination. When the drugs were injected together, the plasma concentrations of R 8110 were initially much higher than after separate injection of R 8110, but they became similar after 30 min. Although statistically non‐significant, fentanyl reduced the total plasma clearance of R 8110 (31.1 ± 6.9 MS. 21.9 ± 2.3 ml/kg/min) and decreased the volume of distribution (3.78 ± 1.83 vs. 2.23 ± 0.90 1/kg, P < 0.05). Fentanyl did not alter the elimination half‐life ofR8110. R8110 had no apparent influence on the pharmacokinetics of fentanyl.