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The oxidative metabolism of fenbendazole: a comparative study
Author(s) -
SHORT C. R.,
FLORY W.,
HSIEH L. C.,
BARKER S. A.
Publication year - 1988
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1988.tb00120.x
Subject(s) - fenbendazole , oxfendazole , metabolite , catfish , metabolism , oxidative phosphorylation , chemistry , incubation , biology , biochemistry , anthelmintic , fish <actinopterygii> , fishery , zoology
Short, C.R., Flory, W., Hsieh, L.C. & Barker, S.A. The oxidative metabolism of fenbendazole: a comparative study. J, vet. Pharmacol. Therap. 11, 50–55. The oxidative metabolism of fenbendazole (FBZ) was studied in hepatic fractions prepared from livers of cattle, sheep, goats, chickens, ducks, turkeys, rats, rabbits and catfish. All species produced the sulfoxide metabolite (oxfendazole; FBZ‐SO), and p ‐hydroxyfenbendazole (FBZ‐OH) was produced by all species except sheep. The product of demethoxycarbonylation, fenbendazole amine (FBZ‐NH 2 ), was not produced by liver preparations of any species. A fourth metabolite, resulting from the further oxidation of oxfendazole, fenbendazole sulfone (FBZ‐S0 2 ), was formed in all species but at highly varying rates. The chicken exhibited the highest overall rate of FBZ metabolism, followed by the duck, goat, sheep, steer, catfish, rat, rabbit, and turkey. Considerable variation was evident among avian species, the duck and turkey produced substantially less of the FBZ‐OH and FBZ‐SO 2 metabolites than the chicken. Catfish liver preparations formed equivalent amounts of metabolite at 25 o C and 37 o C incubation temperatures. The formation of the sulfone metabolite (FBZ‐SO 2 ), however, was practically nonexistent in catfish.