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Comparison of the effects of etomidate and its fluoro analogue, R 8110, on plasma Cortisol, 11β‐deoxycortisol, 17α‐hydroxyprogesterone and testosterone concentrations in dogs
Author(s) -
COSTER R. DE,
DEGRYSE A.D. A. Y.,
DIJK P. VAN,
OOMS L. A. A.,
LAGERWEIJ E.
Publication year - 1987
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1987.tb00533.x
Subject(s) - etomidate , testosterone (patch) , medicine , endocrinology , chemistry , hydrocortisone , steroid , hormone , anesthesia , propofol
R 8110, an imidazole derivative, was shown to be clinically superior to etomidate for induction and maintenance of anaesthesia in dogs. The present study compared the effects of intravenous (i.v.) R 8110, etomidate and Ringer solution on Cortisol biosynthesis by the adrenal gland in seven male labradors. A tetracosactide challenge was carried out 30 min after the i.v. injection of 3 mg/kg of both drugs and after i.v. Ringer solution (1 ml/kg). Etomidate and R 8110 both suppresed the Cortisol response to tetracosactide almost completely and increased the plasma 11β‐deoxycortisol levels more than 20 fold. Maximal 11β‐deoxycortisol values were reached 120 min after R 8110, and not less than 300 min after etomidate. Plasma 17α‐hydroxyprogesterone and testosterone concentrations did not differ between placebo and R 8110 treatment, but they decreased after etomidate. These results indicate that the effects of R 8110 on steroid biosynthesis in dogs are less pronounced than those of etomidate and are largely limited to a temporary inhibition of the 11β‐hydroxylase in the adrenal gland.