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Antinociceptive actions of intravenous a 2 ‐adrenoceptor agonists in sheep
Author(s) -
NOLAN A.,
LIVINGSTON A.,
WATERMAN A.
Publication year - 1987
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1987.tb00530.x
Subject(s) - idazoxan , xylazine , clonidine , nociception , (+) naloxone , pharmacology , chemistry , alpha 2 adrenergic receptor , yohimbine , adrenergic receptor , anesthesia , opioid , medicine , receptor , antagonist , ketamine , biochemistry , prazosin
The antinociceptive activity of the intravenously administered α 2 ‐adrenoceptor agonists, clonidine and xylazine, was measured in sheep using thermal and mechanical pressure threshold detection systems. Both drugs demonstrated clear antinociceptive activity for both forms of threshold stimuli and clonidine at 6 μg/kg i.v. was more potent and longer lasting than xylazine at 50 μg/kg i.v. The antinociceptive effects were reversed by idazoxan (0.1 mg/kg i.v.), but were not affected by naloxone at 0.2 mg/kg i.v. indicating that these effects were mediated by (X2‐adrenoceptors.