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Pharmacokinetics of oxfendazole in goats: a comparison with sheep
Author(s) -
BOGAN J.,
BENOIT E.,
DELATOUR P.
Publication year - 1987
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1987.tb00106.x
Subject(s) - oxfendazole , pharmacokinetics , bioavailability , dose , pharmacology , plasma concentration , oral administration , zoology , pharmacodynamics , medicine , veterinary medicine , anthelmintic , biology , fenbendazole
Bogan, J., Benoit, E. & Delatour, P. Pharmacokinetics of oxfendazole in goats: a comparison with sheep. J. vet. Pharmacol. Therap. 10 , 305–309. In goats, there was a linear correlation of area under the plasma concentration–time curve (AUC) with dose in the range 0–20 mg/kg as single dosages of oxfendazole (OFZ). The bioavailability of OFZ after oral administration was lower in goats than in sheep. The repetition of three administrations at 24 h intervals produced significant increase in the AUC in comparison with a single administration equivalent to the total dosage (1 × 5.0 and 3 × 1.7 mg/kg). Infection with O. circumcincta produced a 33% decrease in the bioavailability of OFZ.