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Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals
Author(s) -
CRAIG A. M.,
BLYTHE L. L.,
APPELL L. H.,
SLIZESKI M. L.
Publication year - 1987
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1987.tb00105.x
Subject(s) - dimethyl sulfoxide , drug , interference (communication) , pharmacology , chemistry , chromatography , computational biology , medicine , biology , computer science , organic chemistry , telecommunications , channel (broadcasting)
Craig, A.M., Blythe, L.L., Appell. L.H. & Slizeski, M.L. Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals. J. vet. Pharmacol. Therap. 10 , 298–304. Dimethyl sulfoxide (DMSO) had been postulated to be a ‘masking agent’ when used concurrently with therapeutic or prohibited drugs in racing animals. Eight drugs (flunixin, furosemide, caffeine, apomorphine, phenylbutazone, lidocaine, cocaine, and acepromazine maleate) were administered to six horses singly and with concurrent intravenous DMSO. Urine samples were analyzed for the presence of the drugs and/or their metabolites by thin layer chromatography. Direct comparison of thin layer chromatograms of extracts of positive urine samples with and without DMSO verified that DMSO did not interfere with the detection of these drugs.