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Clinical evaluation of R 51163, a new sedative in cattle
Author(s) -
DEGRYSE A.D.,
OOMS L. A. A.
Publication year - 1986
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1986.tb00058.x
Subject(s) - sedation , sedative , medicine , anesthesia , ice calving , zoology , biology , pregnancy , lactation , genetics
Degryse, A.‐D. & Ooms, L. A. A. Clinical evaluation of R 51163, a new sedative in cattle. J. vet. Pharmacol. Therap. 9 , 376–384. R 51163, a purine alkyl piperidine derivative, has been shown to produce reliable sedation in cattle of varying age and breed in three different types of experiments: transport and regrouping of cattle which had only been handled occasionally; manipulations and minor interventions; minor and major surgery with or without supplementary local anaesthesia. With dose rates of R 51163 at 0.05 mg/kg i.v. and of 0.10‐0.15 mg/kg i.m. sedation became prominent within 10–15 min and lasted at least 60 min. Caesarian sections were performed under adequate sedation with R 51163 with dose ranging from 0.018 to 0.05 mg/kg i.v. and from 0.075 to 0.10 mg/kg i.m. The data suggest possible increased responsiveness to the drug at the time of calving.