Premium
Characterization of a Pasteurella multocida (serotype B) bovine pneumonic pasteurellosis model and the effect of antimicrobials during peracute infection
Author(s) -
FURROW R. D.,
PARBUONI E. L.,
McRAE D. T.,
GAINES S. A.,
GUARNIERI J. A.,
CARNEVALE R. A.,
APRIL M.
Publication year - 1986
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1986.tb00040.x
Subject(s) - pasteurellosis , pasteurella multocida , serotype , microbiology and biotechnology , pasteurella , antimicrobial , bovine respiratory disease , pneumonia , biology , tilmicosin , inoculation , virology , antibiotics , medicine , immunology , bacteria , genetics
A method to produce bovine pneumonic pasteurellosis for experimental purposes was studied and the clinical response of experimentally infected calves to selected antimicrobials was characterized. Male Holstein calves stressed with multiple hot and cold water applications followed by intratracheal inoculation of broth cultures of Pasteurella multocida serotype B developed acute clinical illness consistent with pneumonia. Infected, untreated calves consistently developed classic pneumonic pasteurellosis, infected calves treated with either oxyletracycline or sulfadimethoxine recovered from acute clinical disease, and the uninfected controls remained healthy. This disease model offers potential for use in pharmacokinetic and target tissue drug concentration studies and for dosage titration of drugs intended for treatment of bacterial pneumonias.