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Pharmacokinetics of lithium in the dog
Author(s) -
ROSENTHAL R. C.,
KORITZ G. D.,
DAVIS L. E.
Publication year - 1986
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1986.tb00015.x
Subject(s) - pharmacokinetics , lithium carbonate , bioavailability , lithium (medication) , volume of distribution , pharmacology , oral administration , distribution (mathematics) , chemistry , lithium chloride , medicine , mathematics , ion , mathematical analysis , organic chemistry , ionic bonding
The pharmacokinetics of lithium were determined in eight adult dogs. The data were fitted to a two‐compartment model. Single intravenous doses of lithium chloride, and single oral doses of lithium carbonate were used. The mean plasma lithium half‐life (l ½ ) following the single intravenous dose was 21.6 h, and the mean apparent specific volume of distribution of the central compartment (V′ c ) was 0.189 l/kg. Mean bioavailability was 78.8% following oral administration.