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Sulfatroxazole: pharmacokinetics, metabolism and urinary excretion in goats and pigs
Author(s) -
KINABO L. D. B.,
NIELSEN POUL
Publication year - 1986
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1986.tb00012.x
Subject(s) - urine , pharmacokinetics , excretion , chemistry , endocrinology , metabolism , medicine , urinary system , biology
The disposition of sulfatroxazole (STZ) has been studied in goats and pigs after intravenous administration of a single dose. The percentage of protein‐binding decreased with increasing plasma concentration in both species. At 100 μg/ml about 85% was bound to plasma proteins in goats, while the corresponding value was only 55% in pigs. Two metabolites of STZ were isolated from urine and identified as N 4 ‐acetyl‐STZ and 3‐sulfaniIarnido‐4‐methyl‐5‐hydroxy‐methyl‐isoxazole (5′‐OH‐STZ). The goats excreted about 80% of the dose in urine. The majority (64%) was excreted as unchanged STZ, while N 4 ‐acetyl‐STZ and 5′‐OH‐STZ made up 19% and 18%, respectively. The pigs excreted 95% of the dose in urine. Unchanged STZ amounted to 30% and N 4 ‐acetyl‐STZ to 70% of the urinary excretion in pigs, while there were only traces of 5′‐OH‐STZ.