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Ibuprofen prevents Pasteurella hemolytica endotoxin‐induced changes in plasma prostanoids and serotonin, and fever in sheep
Author(s) -
EMAU P.,
GIRI S. N.,
BRUSS M. L.,
ZIA SHAHEEN
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00967.x
Subject(s) - ibuprofen , serotonin , pharmacology , chemistry , medicine , microbiology and biotechnology , biology , receptor
Intravenous infusion of Pasteurella hemolytica endotoxin caused marked increases in the plasma levels of thromboxane B 2 (TxB 2 ), prostaglandins (PG) and serotonin in sheep. The control values for TxB 2 , 6‐keto‐PGF 1a , PGF 2a , and serotonin before endotoxin infusion averaged 283 ± 53 (standard error of mean), 281 ± 14 and 199 ± 27 pg/ml and 57 ± 3 ng/ml, respectively. At 50 min during endotoxin infusion, these values were increased to their maximum of 376, 339, 325 and 202% of control, respectively. Body temperature increased from the control value of 39.5 ± 0.1åC to a maximum of 41.5 ± 0.1åC at 200‐300 min of infusion. In the second part of this study, we have examined the effects of ibuprofen on endotoxin‐induced increases in plasma PG, TxB 2 , and serotonin levels and body temperature. The control values for TxB 2 , 6‐keto‐PGF 1a , PGF 2a , and temperature prior to ibuprofen and endotoxin infusion averaged 238 ± 35, 335 ± 44 and 248 ± 28 pg/ml, 65 ± 3 ng/ml and 40.1 ± 0.2åC, respectively. A loading dose (15 mg/kg) of ibuprofen was followed by infusion of endotoxin (12 μg/kg) and ibuprofen (43.3 mg/kg) over 500 min. Plasma levels of 6‐keto‐PGF 1a and serotonin increased only to 131 and 149% of control at 50 min of infusion, and levels of PGF 2a and TxB 2 decreased to 50 and 80% of control at 100 and 150 min of infusion, respectively. Temperature remained unchanged. Ibuprofen effectively suppressed endotoxin‐induced increases in the plasma levels of TxB 2 , 6‐keto‐PGF 1a , PGF 2a , and serotonin and body temperature. It was concluded from the present study that nonsteroidal anti‐inflammatory drugs as an adjunct to antibiotic therapy might have a rational basis in treatment of endotoxin toxicity.