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Some dynamic and toxic effects of theophylline in horses
Author(s) -
ERRECALDE J. O.,
BUTTON C.,
MÜLDERS M. S. G.
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00962.x
Subject(s) - theophylline , aminophylline , medicine , diuresis , anesthesia , tachycardia , pharmacology , renal function
Errecalde, J.O., Button, C. & Mülders, M.S.G, Some dynamic and toxic effects of theophylline in horses. J. vet. Plmrmacol. Therap. 8, 320–327. A single intravenous administration of theophylline as aminophylline at 10 mg/kg to four mares induced a diuresis in which maximal urine production was more than seven times the control volume. The diuretic effect was maximal within the first hour post‐administration, and lasted approximately 6 h. Theophylline resulted in dose‐related tachycardia, polypnoea and nervous symptoms (tactile, visual and auditory hypersensitivity, muscle tremor, sweating) in normal mares, but had only minor effects on arterial and central venous blood pressures, intrapleural pressure, red blood cell variables and plasma proteins. The upper limit of safe plasma theophylline concentration in horses is approximately 15 μg/ml. Whenever feasible, the oral or intragastric route of administration should be used as it is safer than the intravenous route. Dr C. Button, Regional Veterinary Laboratory, PO Box 388, Benalla, Victoria 3672, Australia.