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Cardiovascular and respiratory effects of acetylpromazine and xylazine on halothaneanesthetized horses
Author(s) -
STEFFEY E. P.,
KELLY A. B.,
FARVER T. B.,
WOLINER M. J.
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00959.x
Subject(s) - xylazine , respiratory system , medicine , anesthesia , pharmacology , ketamine
Steffey, E.P., Kelly, A.B., Farver, T.B. & Woliner, M.J. Cardiovascular and respiratory effects of acetylpromazine and xylazine on halothane‐anesthetized horses. J. vet. Pharmacol. Therap. 8, 290–302. Circulatory and respiratory effects of intravenously administered acetylpromazine (0.033 and 0.067 mg/kg) and xylazine (0.5 and 1.0 mg/kg) were studied in drug cross‐over fashion in eight laterally recumbent horses anesthetized only with halothane (1.06%, end‐tidal) in O 2 . Both doses of acetylpromazine caused a significant and sustained elevation in cardiac output via a rise in stroke volume. Xylazine produced an initial significant fall in cardiac output followed by a return to control levels. Halothane anesthesia did not prevent xylazine‐related atrioventricular conduction block. All treatments caused a similar significant fall in arterial blood pressure (acetylpromazine, total peripheral resistance‐related; xylazine, cardiac output‐related). PaCO 2 significantly increased after all treatments. PaCC 2 decreased significantly only following xylazine treatment. One horse (not included in the tabulation) developed ventricular fibrillation and died 15 min after receiving its first injection (0.5 mg/kg) of xylazine. Dr E. P. Steffey, Department of Surgery, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.