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Potentiation of the anthelmintic activity of oxfendazole by parbendazole
Author(s) -
HENNESSY D. R.,
LACEY E.,
PRICHARD R. K.,
STEEL J. W.
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00956.x
Subject(s) - oxfendazole , anthelmintic , long term potentiation , pharmacology , traditional medicine , veterinary medicine , biology , medicine , fenbendazole , receptor
Hennessy, D.R., Lacey, E., Prichaid, R.K. & Steel, J.W. Potentiation of the anthelmintic activity of oxfendazole by parbendazole. J. vet. Pharmacol. Therap. 8, 270–275. The ability of parbendazole (PBZ) to potentiate co‐administered oxfendazole (OFZ) was investigated. Administration of a range (1.35–36.0 mg/kg) of doses of PBZ with 4.53 mg OKZ/kg demonstrated that signilicant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the area under the plasma OKZ concentration curve was about twice that obtained from oral administration of OFZ alone. When tested against benzimidazole‐resistant Haemonchus contorolus and Trichostrongylus colubriformis , the mixture of 4.5 mg PBZ + 4.53 mg OKZ/kg was significantly more effective than 4.53 mg OFZ/kg alone, and PBZ alone showed no activity against these resistant nematodes. The demonstration of PBZ‐OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis. Dr D. R. Hennessy, CSIRO Division of Animal Health, McMaster Laboratory, Private Bag No. 1, PO, Glebe, NSW 2037, Australia.