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The effect of copper on intact cattle erythrocytes
Author(s) -
ASANO R.,
HOKARI S.
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00939.x
Subject(s) - copper , chemistry , hemolysis , in vitro , potassium , in vivo , incubation , sodium , glutathione , bovine serum albumin , albumin , pharmacology , biochemistry , medicine , biology , microbiology and biotechnology , enzyme , organic chemistry
Asano, R. & Hokari, S. The effect of copper on intact cattle erythrocytes. J. vet. Pharmacol. Therap. 8, 157–164. The effect of copper on intact cattle erythrocytes was investigated in vitro. When treated with copper, a decrease in the GSH content, accumulation of copper in the cell, loss of potassium and gain of sodium, cross‐linking of membrane proteins, and echinocytic transformation were observed. All of these phenomena seem to be caused by a potent oxidant action of copper. These icy totoxic effects of copper were markedly inhibited by the addition of bovine serum albumin in the incubation medium. These results may help to understand the mechanism of hemolysis associated with copper poisoning in vivo.Ryuji Asano, Department of Veterinary Pharmacology, College of Agriculture and Veterinary Medicine, Nihon University, Kameino, Fujisawa, Kanagawa 252, Japan.