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Clinical pharmacology of apramycin in calves
Author(s) -
ZIV G.,
BOR A.,
SOBAGK S.,
ELAD D.,
NOUWS J. F. M.
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00930.x
Subject(s) - clinical pharmacology , pharmacology , computational biology , medicine , biology
Ziv, G., Bor, A., Sohack, S., Elad, D. & Nouws, J.F.M. Clinical pharmacology of apramycin in calves. J. vet. Pharmacol. Therap. 8, 95–104. The minimal inhibitory concentrations (MIC) of apramycin, a unique aminocy‐clitol antibiotic, were compared with the MIC of dihydrostreplomycin and neomycin for 323 Salmonella , 178 Escherichia coli and twenty‐six Pasteurella multocida isolates recovered from newborn calves. Apramycin exhibited better in vitro anti‐bacterial activity than dihydrostreptomycin and neomycin; isolates of Salmonella group B and E. coli resistant to the latter were sensitive to apramycin. The durations of free drug concentrations in the tissues after i.v. and i.m. injection were estimated from the serum drug level data, percent of serum protein binding, V dss , 1/2ß and the MIC. Computations showed that apramycin should be administered i.m. at 20 mg/kg every 24 h in order to maintain in tissues potentially effective drug concentrations sufficient to inhibit 50% of the Salmonella, E. coli , and P. inullocida isolates, and at 12‐h intervals to inhibit 90% of the isolates. G. Ziv, Ministry of Agriculture, Kimron Veterinary Institute, P.O. Box 12, Bet Dagan, Israel.