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Distribution of oxytetracycline into ocular tissues and tears of calves
Author(s) -
GEORGE LISLE W.,
SMITH J. A.,
KASWAN RENEE
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00923.x
Subject(s) - oxytetracycline , tears , conjunctiva , aqueous humour , lacrimal gland , ophthalmology , medicine , distribution (mathematics) , tissue distribution , veterinary medicine , chemistry , physiology , aqueous humor , antibiotics , surgery , pathology , biochemistry , mathematical analysis , mathematics
George, L., Smith, J. & Kaswan, R. Distribution of oxytetracycline into ocular tissues and tears of calves. J. vet. Pharmacol. Therap. 8, 47–54. A long‐acting oxytetracycline formulation was administered (20 mg/kg of body weight) intramuscularly to calves, and the concentrations of the drug in serum, ocular tissues and tears were measured. The drug was distributed selectively to the epithelium of the conjunctiva and to the lacrimal gland ductules, and reached concentrations in each tissue that exceeded those in serum. The drug did not penetrate into the aqueous humour, and produced mean peak lacrimal fluid concentrations <1 μg/ml after i.m. administration. When given subconjunctivally, however, concentrations > 2.0 μg/ml were observed in tears for 72 h. Severe local reactions occurred in all calves that were given the drug subconjunctivally. Lisle W. George, Department of Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.