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Pharmacokinetics and bioavailability of theophylline in horses
Author(s) -
ERRECALDE J. O.,
BUTTON C.,
BAGGOT J. D.,
MULDERS M. S. G.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00910.x
Subject(s) - theophylline , aminophylline , bioavailability , pharmacokinetics , volume of distribution , pharmacology , chemistry , oral administration , medicine , biochemistry
The pharmacokinetics and bioavailability of theophylline in horses were investigated following both intravenous and intragastric administration of aminophyllinc solutions at doses, corresponding to 15 and 10 mg/kg theophylline base. A rapid distributive phase with a half‐life of approximately 15‐30 min was followed by a slower elimination half‐life averaging 15‐17h. The apparent volume of distribution averaged 850‐900 ml/kg. Theophylline, administered as aminophylline solution, was both rapidly and completely absorbed from the equine digestive tract. Based on the bioavailability and disposition kinetics of theophylline, an intragastric dosage regimen for aminophylline consisting of the administration of 5 mg/kg at 12h intervals would be expected to maintain plasma theophylline concentrations within the therapeutic range.