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Effects of dipyrone on endotoxininduced fever, central nervous depression and hypoglycaemia in sheep
Author(s) -
NAYLOR J. M.,
CATANZARRO C. A.,
KRONFELD D. S.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00905.x
Subject(s) - saline , central nervous system , depression (economics) , medicine , anesthesia , endocrinology , pharmacology , biology , zoology , chemistry , macroeconomics , economics
Sixteen sheep were divided into four groups and were given saline, Escherichia coli endotoxin at 35 μg/kg 0.75 , dipyrone at 88 mg/kg 0.75 , or endotoxin and dipyrone intravenously. Plasma glucose concentrations, rectal temperature and depression of central nervous function were assessed at hourly intervals for 10 h and again at 24 h. Dipyrone had no effect on normal sheep but in sheep given endotoxin, it blocked the febrile response and partially blocked the depression effect upon the central nervous system without affecting the hypoglycaemic response.