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A health index to evaluate clinically a ß‐hemolytic streptococcal infectious disease model in the horse
Author(s) -
POWERS J. D.,
POWERS T. E.,
VARMA K. J.,
GABEL A. A.,
SPURLOCK S. L.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00902.x
Subject(s) - disease , medicine , clinical trial , clinical disease , drug trial , horse , infectious disease (medical specialty) , drug , index (typography) , intensive care medicine , biology , pharmacology , computer science , paleontology , world wide web
Quantification of the clinical manifestations of a disease has been a serious problem particularly as related to clinical trials or drug efficacy studies. Historically, this quantification has been limited to categorizing each patient into one of three or four groups, e.g. worse, no improvement, improved. This problem becomes serious when an investigation utilizes an experimentally induced animal disease model. A health index, which quantifies the clinical state of horses which have an experimentally induced ß‐hemolytic streptococcal infection, is described. Aspects of experimental design and statistical analysis are also discussed in relationship to the use of the index for drug efficacy studies.