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Gastro‐intestinal motor disturbances induced by lysine‐acetylsalicylate treatment in sheep
Author(s) -
HONDE C.,
BUÉNO L.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00899.x
Subject(s) - tolazoline , phentolamine , intestinal motility , motility , chemistry , oral administration , medicine , pharmacology , endocrinology , anesthesia , propranolol , biology , genetics
The effects of intravenous (i.v.), intramuscular (i.m.) and oral administration of lysine‐acetylsalicylate (Lys‐ASA) on gastro‐intestinal motility were investigated in sheep using electromyography. A dose of 20 mg/kg Lys‐ASA intravenously reduced the frequency of reticular contractions for 86 ± 18 min, produced abomasal hypomotility and caused a disruption of the cyclical pattern of intestinal motility for at least 120 min. The frequency of reticular contractions measured from 20 to 30 min after Lys‐ASA administration was negatively correlated (ß= 0.97; PΔ0.01) to the log of the dose used for doses varying from 10 to 40 mg/kg. Similar effects were observed with intramuscular and oral dose rates of 40 and 80 mg/kg, respectively. Previous i.v. administration of phentolamine (0.1 mg/kg) or tolazoline (2 mg/kg) abolished the effects of Lys‐ASA (20 mg/kg) administered intravenously on both reticular contractions and abomaso‐intestinal motility. It was concluded that Lys‐ASA administered at therapeutic doses in sheep produced gastro‐intestinal motor disturbances and that α‐and α 2 ‐adrenergic antagonists are able to block them.