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Effects of tryptamine antagonists on the anaphylactic contractions of the bovine pulmonary smooth muscles
Author(s) -
OGUNBIYI P.O.,
EYRE P.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00892.x
Subject(s) - methysergide , ketanserin , trachealis muscle , chemistry , medicine , serotonin , anesthesia , pharmacology , endocrinology , 5 ht receptor , receptor , asthma , bronchoconstriction
Calves were sensitized with horse plasma (H.P.), 0.2 ml/kg, i.v., and H.P. (0.2 ml/ kg) in Freund's complete adjuvant, s.c. The latter injection was repeated 1 week later and the animals were killed 10 days after the second injection. Spirally cut strips of pulmonary artery and vein and the trachealis muscle from the sensitized calves contracted to 5‐hydroxytryptamine (5‐HT) and specific antigen (horse plasma). Antigen‐induced contractions of the pulmonary smooth muscles were significantly blocked (P<0.05) by the 5‐HT antagonists, methysergide and ketanserin. The trachea, however, appeared less sensitive to the antagonists than the pulmonary vessels. The results suggest that 5‐HT participates in the pulmonary anaphylactic reactions of cattle and that ketanserin may be useful in suppressing bovine pulmonary hypersensitivities.