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A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues
Author(s) -
DELATOUR P.,
GARNIER F.,
BENOIT E.,
LONGIN CH.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00890.x
Subject(s) - albendazole , oxfendazole , metabolite , chemistry , toxicity , pharmacology , plasma concentration , metabolism , drug , biochemistry , anthelmintic , biology , organic chemistry , fenbendazole , ecology
The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to foetal tissues were studied using two drugs, albendazole and oxfendazole. In the rat, the metabolic inhibitor, SKF‐525A, induced changes in embryotoxicity which were well correlated with plasma levels of identified embryotoxic metabolites, but not with the levels of foetal tissue bound drug metabolites.