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Plasma concentration, mammary excretion and side‐effects of phenylbutazone after repeated oral administration in healthy cows
Author(s) -
MARTIN K.,
ANDERSSON L.,
STRIDSBERG M.,
WIESE B.,
APPELGREN L.E.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00889.x
Subject(s) - phenylbutazone , excretion , plasma concentration , medicine , side effect (computer science) , endocrinology , pharmacology , chemistry , computer science , programming language
Seven clinically healthy dairy cows were each given 2.5 gphenylbutazone (approximately 5 mg/kg body weight) by oral administration twice daily for 8 days. The concentrations of phenylbutazone in plasma and milk and several blood parameters were studied. The minium plasma concentration during steady state was 100.4 ± 7.3 μg/ml. During the same period the milk concentration never exceeded 1% of the plasma concentration. The elimination half‐life in plasma was 38.6 ± 3.7 h. Five days after administration had been discontinued, the milk concentration was 0.05 ± 0.01 μg/ml. All seven cows were clinically healthy throughout the experiment. The most pronounced side‐effect of the blood parameters studied was a decreased concentration of leucocytes to about two‐thirds of the control value. This might have a pronounced influence on the effectiveness of the immune system. There was also a significant decrease in total bilirubin indicating a decrease in the breakdown of erythrocytes.