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Effects of erythromycin‐inactivating Lactobacillus crop flora on blood levels of erythromycin given orally to chicks
Author(s) -
DEVRIESE L. A.,
DUTTA G. N.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00878.x
Subject(s) - erythromycin , broiler , lactobacillus fermentum , biology , microbiology and biotechnology , antibiotics , lactobacillus , strain (injury) , crop , macrolide antibiotics , flora (microbiology) , food science , veterinary medicine , bacteria , medicine , lactic acid , agronomy , fermentation , lactobacillus plantarum , genetics , anatomy
Germ‐free, day‐old chickens were colonized with a Lactobacillus fermentum strain isolated from poultry which was able to inactivate in vitro erythromycin and other macrolide and lincosamide antibiotics. Similar control chickens were colonized with a non‐degrading L. fermentum strain. Only in chickens colonized with the non‐degrading strain were blood levels considered to be therapeutically active achieved with erythromycin in the drinking water. Five groups of broiler chickens of different age originating from three farms all possessed an erythromycin‐degrading crop flora. In none of these were therapeutic blood levels attained when erythromycin was given in the drinking water.