Premium
Clinical pharmacokinetics of carbenicillin, carfecillin, ticarcillin and BL‐P 1654 in dairy cows
Author(s) -
NOUWS J. F. M.,
ZIV G.,
GINNEKEN C. A. M.,
VREE T. B.
Publication year - 1984
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1984.tb00876.x
Subject(s) - ticarcillin , carbenicillin , udder , antibiotics , microbiology and biotechnology , pharmacokinetics , klebsiella , medicine , minimum inhibitory concentration , chemistry , biology , pharmacology , gentamicin , escherichia coli , mastitis , amoxicillin , clavulanic acid , biochemistry , gene
The minimal inhibitory concentrations (MIC) of carbenicillin, ticarcillin and BL‐P 1654 for gram‐negative udder pathogens were determined using the agar plate dilution method. The MIC of the drugs for 50% and 90% of the isolates examined ranged for Escherichia coli and Aerobacter spp. from 1.56 to 25 μg/ml, and for Klebsiella spp. and Pseudomonas spp. from 3.12 to 50 μg/ml. The Serratia spp. were relatively non‐susceptible for the drugs studied (MIC greater than 50μg/ml). Each drug was administered intravenously at 5 g and 15 g per cow to different groups of cows with normal and inflamed quarters of the udder. Distribution and elimination kinetic parameters calculated from serum drug level data were very similar to those of other beta‐lactam antibiotics. Although drug concentrations in milk from inflamed quarters were higher than in milk from normal quarters, they were considerably below the MIC for the majority of gram‐negative udder pathogens. The data suggest that parenteral treatment of gram‐negative udder infections with carbenicillin, carfecillin, ticarcillin and BL‐P 1654 at the dose levels used in the present study is unlikely to result in a bacteriological cure and would probably be clinically ineffective.