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Pharmacokinetics of imidocarb in normal dogs and goats
Author(s) -
ABDULLAH A. SALAM,
BAGGOT J. DESMOND
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00464.x
Subject(s) - pharmacokinetics , volume of distribution , bolus (digestion) , jugular vein , chemistry , zoology , intravenous bolus , veterinary medicine , pharmacology , anesthesia , medicine , biology
The pharmacokinetics of imidocarb were studied in seven mongrel dogs and eight crossbred goats. An intravenous bolus dose (4 mg/kg) of 12% imidocarb dipropionate solution wasinjected into the cephalic vein in dogs and the jugular vein in goats. The plasma concentration of imidocarb was measured by spectro‐photometry. The experimental data were analysed using a two‐compartment open model. The apparent volume of the central compartment was significantly higher ( P <0.01) in dogs than in goats. The significantly larger ( P <0.05) apparent specific volume of distribution in goats than in dogs may be attributed to passive diffusion followed by ion trapping of the drug in rumen fluid. Neither the half‐life nor body clearance differed significantly between dogs ( t 1/2 , 207 ± 45 min; Cl B , 1.47 ± 0.38 ml/min kg) and goats ( t 1/2 , 251 ± 94 min; Cl B , 1.62 ± 0.50 ml/min kg). While almost 80% of the dose had been eliminated at 8 h in. both species, the high ratio of the imidocarb level in the peripheral‐to‐central compartment in goats suggests that a prolonged period may be required for complete elimination of the drug.