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The effect of antibiotics on mannose‐resistant haemagglutination by K88‐ and K99‐positive Escherichia coli strains
Author(s) -
SØGAARD H.,
LARSEN J. L.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00463.x
Subject(s) - oxytetracycline , streptomycin , microbiology and biotechnology , ampicillin , neomycin , polymyxin b , chloramphenicol , hemagglutination , gentamicin , colistin , antibiotics , dihydrostreptomycin , bacitracin , polymyxin , biology , chemistry , virology , virus
Five E. coli strains carrying K99 antigen isolated from the intestines of calves which had succumbed to diarrhoea and six K88‐positive strains isolated from fatal cases of diarrhoea in piglets were examined for their mannose‐resistant haemagglutination (MRHA) capacity against pig erythrocytes. The bovine strains showed a geometric mean MRHA‐titre of 1/18 and the porcine strains one of 1/45. Similar experiments were carried out after addition of the following antibiotics in doubling dilutions: ampicillin, chloramphenicol, colistin, dihydro‐streptomycin, gentamicin, neomycin, polymyxin B and oxytetracycline. Colistin and polymyxin B had a marked concentration‐dependent inhibitory effect on MRHA. Neomycin and gentamicin also inhibited MRHA but to a lesser degree. Chloramphenicol, dihydrostreptomycin and oxytetracycline showed no effect. With ampicillin, a trend was found for the ratio values to be inversely proportional to the concentration. This suggests that this antibiotic has an enhancing effect on the haemagglutination.