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Comparison of pharmacokinetics of sodium and lysine cephalexin in calves
Author(s) -
CARLI S.,
PERRETTA G.,
BRUSA T.,
INVERNIZZI A.,
FAUSTINI R.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00462.x
Subject(s) - pharmacokinetics , lysine , pharmacology , chemistry , sodium , intramuscular injection , oral administration , distribution (mathematics) , medicine , biochemistry , amino acid , mathematics , organic chemistry , mathematical analysis
The pharmacokinetics of sodium and lysine cephalexins were investigated after intravenous and intramuscular administration of a single dose rate of 30 mg.kg ‐1 body weight in calves. The data for the two salts administered intravenously were pooled, the resulting pharmacokinetic disposition of cephalexin indicating a distribution half‐time ( t 1/2 α) and an elimination half‐time ( t 1/2 β) of 9.78 and 62.0 min, respectively. Following intramuscular administration some pharmacokinetic differences were recorded between the cephalexin preparations: lysine cephalexin was more rapidly eliminated ( t 1/2 k el = 55.2 min) than sodium cephalexin ( t 1/2 k el = 89.8 min), although the peak blood level was higher and attained after a longer time with lysine cephalexin.