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Placental transfer and renal clearance of sulphamethoxazole and its metabolite N 4 ‐acetylsulphamethoxazole in a pregnant ewe
Author(s) -
VREE TOM B.,
REEKERSKETTING JOKE J.,
NOUWS JAC F. M.,
ARTS THEO H. M.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00458.x
Subject(s) - metabolite , chemistry , pharmacology , medicine
Sulphamethoxazole and its metabolite, N 4 ‐acetylsulphamethoxazole, were shown to cross the placenta of a pregnant ewe. The plasma concentration of N 4 ‐acetylsulphamethoxazole increased in the foetus due to the limited elimination properties of the immature kidney. The amniotic fluid concentration of sulphamethoxazole and N 4 ‐acetylsulphamethoxazole were low, amounting to 2.0 and 0.46μg/ml respectively. Protein binding of the sulphonamides was slightly higher in the foetus than in the ewe.