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Pharmacokinetics of lidocaine and its active metabolites in dogs
Author(s) -
WILCKE J. R.,
DAVIS L. E.,
NEFFDAVIS C. A.,
KORITZ G. D.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00454.x
Subject(s) - lidocaine , pharmacokinetics , lidocaine hydrochloride , absorption (acoustics) , pharmacology , absorption rate , chemistry , intramuscular injection , anesthesia , plasma concentration , metabolite , medicine , chromatography , biochemistry , physics , acoustics
The pharmacokinetics of lidocaine in dogs were investigated following the intravenous and intramuscular administration of single doses of lidocaine hydrochloride. The mean elimination rate constant and the mean specific clearance determined for the intravenous portion of the study were 0.786 h ‐1 and 2.40 1/kg/h, respectively. Following intramuscular administration the mean absorption rate constant was 7.74 h ‐1 . Absorption was nearly complete as the percentage of an intramuscular dose absorbed averaged 91.9%. Concentrations of two N‐deethylated metabolites, determined following the administration of lidocaine suggest that monoethylglycinexylidide is eliminated rapidly while glycinexylidide is more slowly eliminated. The relative contribution of these metabolites to the therapeutic and toxic effects of lidocaine and the potential for glycinexylidide accumulation during lidocaine administration remain to be investigated.