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The effect of polyethylene glycol‐200 on metabolic acidosis induced by chloralose anaesthesia
Author(s) -
SHUKLA RAJNI,
SHUKLA S. B.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00392.x
Subject(s) - chloralose , saline , polyethylene glycol , chemistry , metabolic acidosis , peg ratio , anesthesia , acid–base homeostasis , zoology , chromatography , medicine , biochemistry , biology , stimulation , finance , economics
Chloralose may be used in a 10% solution as an anaesthetic in dogs. The solubility of chloralose was found to be much higher in polyethylene glycol‐200 (PEG‐200) than in either warm (body temperature) or cold saline (0.9% NaCl). The intravenous (i.v.) administration of chloralose in warm saline solution induced acidosis as a result of the increase in the level of metabolic acids. The acidity generated by chloralose in almost neutral saline was probably the result of increase in the base deficit in the animal. The infusion of PEG‐200 (almost neutral) significantly reduced the base deficit without disturbing the PaO 2 or PaCO 2 in the arterial blood. The base deficit value was significantly lower after administration of chloralose solution in PEG‐200 (almost neutral) than after administration in saline. The use of PEG‐200 as a solvent for chloralose was advantageous in two ways. Firstly, it prevented the production of acids in anaesthetic solution and neutralized the blood metabolic acids generated by chloralose administration in saline. Secondly, the solubility of chloralose (10% w/v solution) in PEG‐200 was very much higher than in warm or cold saline.