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Pharmacokinetics of digoxin in cattle
Author(s) -
KORITZ G. D.,
ANDERSON K. L.,
NEFFDAVIS C. A.,
WILCKE J. R.,
DAVIS L. E.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00391.x
Subject(s) - digoxin , pharmacokinetics , serum concentration , pharmacology , medicine , zoology , chemistry , biology , heart failure
Digoxin was administered as a single intravenous injection of 22 μg/kg to six cattle. The resulting serum concentrations were fitted by both a bi‐ and tri‐exponential equation with the latter providing the best fit to the data of a majority of the animals. The biological half‐life of digoxin in cattle was found to be 7.8 h. This relatively short half‐life in comparison to other animal species dictates that digoxin should be administered more frequently to cattle to provide therapeutic concentrations in serum without broad fluctuations in serum concentrations. Computer simulations of various intravenous dosage regimens suggested that a loading dose of 22 μg/kg followed by an infusion of 0.86 μg/kg/h would offer the greatest safety and efficacy in bovine patients.