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Comparison of pharmacokinetic parameters for two oxytetracycline preparations in pigs
Author(s) -
XIA WENJIANG,
GYRDHANSEN NILS,
NIELSEN POUL
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00387.x
Subject(s) - oxytetracycline , pharmacokinetics , bioavailability , urine , plasma concentration , pharmacology , chemistry , oral administration , medicine , antibiotics , biochemistry
Pharmacokinetics of oxytetracycline (OTC) were studied in 10 pigs after administration of 20 mg/kg body weight of either a conventional (OTC‐C) or a long‐acting (OTC‐LA) preparation. After intravenous administration of OTC‐C the elimination half‐life for OTC was 3.75 h, with approximately 75% of the dose being excreted in the urine in 1 week. Intramuscular (i.m.) injection of OTC‐C resulted in plasma peak values after 4 h, while OTC‐LA after i.m. administration produced the highest plasma levels within 1 h, although these were lower than with OTC‐C. For both preparations the bioavailability after i.m. administration was 95–100% and about 70% of the dose was excreted in the urine during the first week. With OTC‐C given i.m., plasma concentrations above 0.5 μg/ml were maintained for 28 h and with OTC‐LA for 35 h indicating a weak retard effect of the latter. Pronounced tissue damage at the injection site was seen 1 and 2 weeks after the administration of OTC‐LA, while OTC‐C produced very little irritation. OTC could be found at the injection site for 2 weeks, the concentrations being higher for OTC‐LA than for OTC‐C.