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Pharmacokinetic studies of theophylline in cats
Author(s) -
McKIERNAN B. C.,
KORITZ G. D.,
DAVIS L. E.,
NEFFDAVIS C. A.,
PHERIS D. R.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00385.x
Subject(s) - theophylline , aminophylline , pharmacokinetics , volume of distribution , bioavailability , oral administration , cats , bronchodilator , absorption (acoustics) , pharmacology , distribution (mathematics) , medicine , chemistry , anesthesia , mathematics , asthma , mathematical analysis , physics , acoustics
The pharmacokinetics of theophylline were determined in adult cats and the data were fitted to a two‐compartment model. Single intravenous and multiple oral doses of aminophylline were used. The mean plasma theophylline half‐life ( t 1/2 ) following the single intravenous dose was 7.8 h and the mean apparent specific volume of distribution ( V ' d(area) ) was 0.46 l/kg. The absorption half‐life ( t 1/2 ab ) was 0.5 h and the bioavailability was 96% following oral administration. There was excellent agreement between the predicted and observed plasma theophylline concentrations following multiple oral doses.