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Clinical pharmacology and pharmacokinetics of flumequine after intravenous, intramuscular and oral administration in pigeons (Columba livid)
Author(s) -
DORRESTEIN G. M.,
GOGH H. VAN,
BUITELAAR M. N.,
NOUWS J. F. M.
Publication year - 1983
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1983.tb00003.x
Subject(s) - flumequine , pharmacokinetics , pharmacology , oral administration , chemistry , medicine , body weight , antibiotics , ciprofloxacin , biochemistry , enrofloxacin
Dorrestein, G.M., Gogh, H. van, Buitelaar, M.N. & Nouws, J.F.M. Clinical pharmacology and pharmacokinetics of flumequine after intravenous, intramuscular and oral administration in pigeons ( Columba livia ) . J. vet. Pharmacol. Therap. 6, 281–292. The in‐vitro activity of flumequine against 157 strains of bacteria isolated from birds was determined. The minimum inhibitory concentration (MIC) of 96.3% of the Enterobacteriaceae, Proteus spp. and Yersinia pseudotuberculosis studied (n = 135) was ≤1 μg/ml. Pharmacokinetics of flumequine in pigeons ( Columbalivia ) was investigated after intravenous, intramuscular and oral administration. From the blood disappearance curves after i.v. bolus injection (10 mg/kg body weight) clearance rate, blood half‐time and distribution volume were calculated. The recovery of unchanged flumequine from the droppings in 24 h was 37 ± 10% of the administered dose. Flumequine was also given i.m. at two dose levels, 10 and 60 mg/kg body weight. The availability of flumequine as intact drug was 22 and 23%, respectively, in 24 h. Therapeutic blood levels were maintained for 4 and 10 h, respectively. After an oral dose of flumequine (60 mg/kg body weight) an availability of 6.7 ± 2.5% and a peak blood concentration of 2.68 ± 0.92 μg/ml at 2 h after administration were found. The recovery of unchanged flumequine from the droppings in 24 h was 1.55 ± 0.79% of the administered dose. With the exception of the i.m. dose of 10 mg/kg, all flumequine administrations made the pigeons vomit. It appears that blood concentrations below 3 μg/ml will not induce vomiting. On the basis of the present data, a dosage regimen for flumequine in pigeons of a priming dose of 30 mg/kg i.m., followed after 8 h by oral administration of 30 mg/kg, this dose being repeated every 8–12 h, would be expected to give blood concentrations between 1.44 and 2.88 μg/ml.