Premium
Pharmacological aspects of metaldehyde poisoning in mice
Author(s) -
HOMEIDA A. M.,
COOKE R. G.
Publication year - 1982
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1982.tb00500.x
Subject(s) - diazepam , pharmacology , clonidine , medicine , chemistry , anesthesia , endocrinology
Metaldehyde, when administered orally to mice at a dose of 1 g kg ‐1 , produced convulsions and death within 2 h. Brain concentrations of noradrenaline (NA) 5‐hydroxytryptamine (5‐HT) and 5‐hydroxyindoleacetic acid (5‐HIAA) were significantly reduced in these animals relative to controls. Treatment with either intraperitoneal clonidine or diazepam 20 min after administration of metaldehyde reduced the mortality rate and in mice surviving for 5 h, the decrease in brain NA and 5‐HT concentrations were significantly reduced.