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Failure of naloxone to prevent the emetic activity of apomorphine in dogs
Author(s) -
KEITH J. C.,
WILSON R. C.,
BOOTH N. H.,
KEMPPAINEN R.J.
Publication year - 1981
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1981.tb00869.x
Subject(s) - apomorphine , (+) naloxone , morphine , pharmacology , naloxone hydrochloride , narcotic antagonists , agonist , narcotic antagonist , antagonist , medicine , anesthesia , opiate , narcotic , chemistry , receptor
Apomorphine is derived from morphine by acid hydrolysis (DiChiara & Gessa, 1978), and for many years has been used in both human and veterinary medicine as an effective agent for induction of emesis, primarily in cases of poisoning. Since apomorphine is derived from morphine, it was initially thought that it was an opiate receptor agonist similar to morphine. As a result, several medical and veterinary medical pharmacology textbooks recommend reversal of the emetic activity of apomorphine hydrochloride by administration of naloxone hydrochloride, a narcotic antagonist (Klaassen, 1980; Meyers, Jawetz & Goldfien, 1980).