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Effects of Caerulein on exocrine pancreatic secretion in sheep
Author(s) -
BERETTA C.,
ORMAS P.,
BELLOLI C.,
INVERNIZZI A.,
FAUSTINI R.
Publication year - 1981
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1981.tb00733.x
Subject(s) - pancreatic juice , ceruletide , endocrinology , medicine , subcutaneous injection , secretion , chemistry , pancreas , cholecystokinin , receptor
Caerulein administered by slow intravenous infusion at increasing dosage rates (0.1, 1.0, 5.0 and 10.0 ng/kg/min ± 30 min) stimulated pancreatic juice production in sheep as well as the protein content, the amylolytic, the lipolytic and proteolytic activities of pancreatic juice samples collected at 30 min intervals. A long lasting (300 min) infusion of a high dose of Caerulein by subcutaneous route elicited stimulatory effects with reduced intensities, slower onsets but more sustained durations than those produced by the same dose level administered intravenously.