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Residue profile of phenylbutazone in the rabbit. A comparative evaluation by tissue kinetics prior to and post mortem
Author(s) -
TOUTAIN P. L.,
ALVINERIE M.,
RUCKEBUSCH Y.
Publication year - 1980
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1980.tb00490.x
Subject(s) - phenylbutazone , residue (chemistry) , pharmacokinetics , kinetics , chemistry , compartment (ship) , pharmacology , muscle biopsy , endocrinology , medicine , biochemistry , biopsy , biology , physics , oceanography , quantum mechanics , geology
The disposition kinetics and residue levels of phenylbutazone (8 mg/kg) were studied in rabbit. The result suggested that distribution of phenylbutazone can be described by a two open compartment. Elimination half‐time is short (2 h) and estimation of residue levels in muscle, liver and kidney did not differ significantly before and after bleeding. These results suggest that biopsy can be used to determine the phenylbutazone concentration in tissues of larger species. Moreover, using a pharmacokinetic approach based on drug concentrations in plasma, it appears that the mean resting quantity in the peripheral compartment was very close to the experimental data for the muscle.