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Effects of chlorpromazine on plasma concentrations of long chain fatty acids and glucose in sheep
Author(s) -
BRUSS MICHAEL L.
Publication year - 1980
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1980.tb00477.x
Subject(s) - chlorpromazine , propranolol , phentolamine , endocrinology , chemistry , medicine , blockade , epinephrine , biochemistry , receptor
Intravenous chlorpromazine was found to cause rapid increases in plasma concentrations of glucose and long chain fatty acids in adult sheep of both sexes. α‐adrenergic blockade with phentolamine suppressed the increase in glucose concentration but not the increase in concentration of long chain fatty acids caused by chlorpromazine. β‐adrenergic blockade with propranolol suppressed the increase in concentration of long chain fatty acids but not the increase in glucose concentration caused by chlorpromazine. These results were consistent with the hypothesis that chlorpromazine caused a systemic release of epinephrine.