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Pharmacokinetics of lithium in sheep
Author(s) -
MORMÉDE PIERRE,
LEDOUX JEANMARIE
Publication year - 1980
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1980.tb00423.x
Subject(s) - pharmacokinetics , lithium (medication) , pharmacology , absorption (acoustics) , excretion , absorption rate , oral administration , distribution (mathematics) , drug , plasma levels , lithium carbonate , medicine , chemistry , zoology , physiology , biology , chromatography , mathematics , mathematical analysis , ion , physics , organic chemistry , acoustics , ionic bonding
Lithium was administered to adult sheep to estimate its pharmacokinetic parameters and a suitable dosage for chronic psychopharmacological experiments. The triexponential decline of plasma lithium levels was tentatively interpreted with a three‐compartment, open‐model of distribution. Sheep differed from other species by the following features: high faecal excretion of lithium, recycling of lithium through the salivary secretion and low absorption rate of the orally‐administered drug. A chronic oral administration of 1 mmol/kg once daily provided minimal plasma levels of about 1 mmol/l, without toxic side‐effects. The results are discussed with respect to comparative pharmacokinetics of lithium and its potential use in the treatment of behavioral disorders of farm animals.