Premium
The selection of prostaglandin‐F 2 α analogues for luteolysis in cattle
Author(s) -
VRIES H. DE,
FEENSTRA H.
Publication year - 1979
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1979.tb00379.x
Subject(s) - luteolysis , uterotonic , potency , prostaglandin , pregnancy , uterus , zoology , medicine , chemistry , andrology , corpus luteum , biology , biochemistry , oxytocin , in vitro , ovary , genetics
The effects of newly synthesized PG‐F 2 α analogues, mainly belonging to the 13‐thia‐ and Δ 9, 10‐analogues, were investigated using the isolated rate uterus test, the pregnancy interruption test in rats and the pregnancy interruption test in hamsters. The luteolytic action was investigated in cattle. Several compounds were many times more active than PG‐F 2 α. There appeared to be a differentiation between luteolytic and uterotonic potency in the test models used. Some compounds appeared to be good candidates for veterinary clinical use. One compound demonstrated a good luteolytic effect in lactating cows.